HLA-DR Expression on Monocytes and Sepsis Index Are Useful in Predicting Sepsis

The reduction of mortality in patients with sepsis depends on the early identification and treatment at-risk patients. aim was to evaluate HLA-DR expression surface monocytes (MHLA-DR ratio), index (CD64 neutrophils/MHLA-DR C-reactive protein (CRP) development sepsis. We prospectively enrolled 77 critically ill patients, 59 stroke 18 traumatic brain injuries. biomarkers were tested at baseline 3, 6, 9, 12, 15 days later. Most (71%) developed (4.2 ± 1.3 after admission). On day those subsequently developing had lower levels MHLA-DR+ (81.7 16.2% vs. 88.5 12.1%, p < 0.05) higher indexes (0.19 0.19 0.08 0.08, 0.01) than not MHLA-DR ratio slowly recovered before while remained raised septic up 9 (p 0.05). To predict sepsis, optimal cut-offs CRP > 106.90 mg/mL (74.19% sensitivity, 69.49 specificity) rate 72.80% (45.31% 89.47% specificity). periodic monitoring together may help identify ICU increased risk